A risk score incorporating routinely collected clinical information can
identify patients with chronic hepatitis B virus (HBV) infection at high
risk of developing acute-on-chronic liver failure (ACLF) following
severe acute exacerbation, research suggests.
The model distinguished patients who developed ACLF from those who
did not with a concordance index of 0.857 in the derivation cohort and
0.889 in the validation cohort. In comparison, the Model for End-Stage
Liver Disease (MELD) score had a concordance index of 0.601 and 0.632 in
the derivation and validation cohorts, respectively, while the
corresponding values for the Child-Turcotte-Pugh (CTP) score were 0.593
and 0.646.
The model had “good discrimination” and was “superior” to the MELD and CTP scores, say the authors in the World Journal of Gastroenterology.
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Labels: acute-on-chronic liver failure (ACLF), predictors of liver failure